beta-Bungarotoxin, a pre-synaptic toxin with enzymatic activity.
نویسندگان
چکیده
منابع مشابه
Alpha-bungarotoxin (α-Bgtx) and beta-bungarotoxin (β-Bgtx) binding activities in human cadaver brain
Introduction The presence of nicotinic cholinergic receptors in mammalian brain has been suggested by a number of investigators with the application of nicotinic ligands [1, 2]. α-Bgtx is a selective antagonist of postsynaptic nicotinic acetylcholine receptors in vertebrate and insects. By the use of potent nicotinic antagonist Iα-Bgtx as a ligand, cholinergic nicotinic receptors has been ident...
متن کاملInhibition of beta-bungarotoxin action by bee venom phospholipase A2.
(3-Bungarotoxin ((3-BuTX) induces twitching of innervated frog muscle and subsequently blocks transm itter release from motor nerve endings. These actions of P-BuTX are prevented if the nerve-muscle junctions are pretreated with a low concentration of phospholipase A2 from bee venom. When the Ca2+ in the external fluid is replaced by Sr2+, the phospho lipase activity of P-BuTX is negligible an...
متن کاملTriggering enzymatic activity with force.
Integrating single molecule force spectroscopy with fluorescence-based techniques allows the manipulation of an enzyme with a periodic stretching and relaxation protocol while simultaneously monitoring its catalytic activity. After releasing the stretching force we observe a higher probability for enzymatic activity at a time of 1.7 s. A detailed theoretical analysis reveals that the relaxation...
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Amyloid Precursor Protein (APP) is a type I membrane protein that undergoes extensive processing by secretases, including BACE1. Although mutations in APP and genes that regulate processing of APP, such as PSENs and BRI2/ITM2B, cause dementias, the normal function of APP in synaptic transmission, synaptic plasticity and memory formation is poorly understood. To grasp the biochemical mechanisms ...
متن کاملSynaptic Potentials Mediated via a-Bungarotoxin-Sensitive Nicotinic Acetylcholine Receptors in Rat Hippocampal Interneurons
Exogenous application of acetylcholine elicits inward currents in hippocampal interneurons that are mediated via a-bungarotoxin-sensitive nicotinic acetylcholine receptors, but synaptic responses mediated via such receptors have never been reported in mammalian brain. In the present study, EPSCs were evoked in hippocampal interneurons in rat brain slices by electrical stimulation and were recor...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1976
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.73.1.178